Literature summary for 2.1.1.56 extracted from

Varshney, D.; Lombardi, O.; Schweikert, G.; Dunn, S.; Suska, O.; Cowling, V.H.
mRNA cap methyltransferase, RNMT-RAM, promotes RNA Pol II-dependent transcription (2018), Cell Rep., 23, 1530-1542 .

Search for more literature for 2.1.1.56

Activating Compound

Activating Compound	Comment	Organism	Structure
RAM	activating subunit, required for enzyme interaction with RNA	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 66000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
mRNA cap methyltransferase	-	Homo sapiens
RNMT	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	significant loss of RNA polymerase II gene occupancy is observed on enzyme suppression. Enzyme suppression inhibits transcriptional markers including histone H2BK120 ubiquitination, H3K4 and H3K36 methylation, RNA polymerase II C-terminal domain S5 and S2 phosphorylation, and PAFc recruitment	Homo sapiens
physiological function	the enzyme promotes RNA polymerase II-dependent transcription independent of mRNA capping and translation	Homo sapiens

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Release 2023.1 (January 2023)